Letrozole is a drug of the class of aromatase inhibitors that help to reduce the level of estrogen in the body and increase the level of testosterone and gonadotropic hormones.
Letrozole competitively binds to the prosthetic part of cytochrome P450, the aromatase subunit involved in the transformation of androgens to estrone and estradiol, inhibits the biosynthesis of estrogens in tissues and, in particular, eliminates their stimulating effect on tumor growth.
After oral intake is fully absorbed, bioavailability is close to 100%. In the vascular channel, more than half (60%) binds to proteins (mainly albumin), and accumulates in red blood cells. At average therapeutic doses, the equilibrium concentration is achieved in 2-6 weeks. The volume of distribution is 1.9 l / kg. In the liver it breaks down, forming inactive derivatives: T1 / 2 in about 48 hours. It is excreted as the products of biotransformation mainly by the kidneys.
Letrozole induces, with prolonged daily intake, and decreases the level of estrogen in plasma (an average of 85% of the baseline level) in advanced breast cancer () in women over 50 years of age with both sufficient and unknown estrogen receptor levels leading to complete or partial regression of the tumor. In 23% of cases, a decrease in the number of relapses and deaths occurs.
Drug Letrozole – the purpose of the agent in the sphere of medicine
In common medicine, this drug has its own indications:
- early stages of breast cancer express estrogen receptors in postmenopausal women – as adjuvant therapy;
- early stages of breast cancer in postmenopausal women after completion of standard adjuvant Tamoxifen therapy – as extended adjuvant therapy;
- common hormone-dependent forms of breast cancer in postmenopausal women -first-line therapy;
- common forms of breast cancer in postmenopausal women (natural or induced artificially) who received previous therapy with antiestrogens.
In addition, this drug may be prescribed to males for gyno treatment.
Letrozole bodybuilding goals of the medical product during usage
Letrozole bodybuilding is most often used by bodybuilders, but this does not exclude the use of this agent in other sports. In sports practice, this drug is used as another element on the steroid cycle in order to reduce the level of estrogen and increase the testosterone level. Letrozole for men is the most high-quality drug, which is why it is used by many athletes.
Scientists have conducted certain experiments, with the help of which it has been proven that this drug reduces estrogen concentration by almost 100%. At optimal dosages, the concentration of estrogen decreases to 79%, which is also a very good result. A reduced level can influence the decreasing of negative results during the steroid cycle, which is quite important for sportsmen. The use of Letrozole by bodybuilders raises the production of specific hormones that can increase normal androgen levels.
Letrozole for men – the possible side effects of the medication
Like many drugs, the intake of this agent can cause such therapy risks:
2. Painful sensations in the joints.
4. The increase in temperature indicators.
5. The sensation of weakness.
6. The onset of nausea.
7. Increased pressure.
8. Hair loss.
The emergence of such adverse reactions occurs only in violation of recommendations. If you comply with all the rules and do not increase the amount of substance for intake, these symptoms can be avoided.
Letrozole dosage for males during muscle growing courses – good results
Use Letrozole dosages from 1 to 3 milligrams during the day. Experience has shown that the intake of 100 mg per day also has a good effect on the suspension of the aromatization process. The increase in optimal doses leads to side effects, for example, a decrease in libido. Each athlete chooses a dosage in accordance with his or her experience of using steroids and the characteristics of his or her body, but do not take more than 3 milligrams per day. To find out which is the best dose of the drug to apply, you can undergo a medical examination. In the period of prolonged use of the drug, you can use it in a day.
Letrozole bodybuilding buy online fast and for a great price
Letrozole for sale can be bought in a professional sports medicine stores for a rather affordable price. Buy the drug online that is used in various sports to be sure that the cost of it is acceptable for everyone.
Many athletes consider this drug to be one of the most effective and safe options. In addition, the popularity of it can be explained by the fact that it is one of the cheapest among other anti-estrogens.